Description:
Rapid Mixer Granulator is designed to achieve excellent mixing and consistent granules at lower operating cost along with higher productivity. Better mixing and closed control of granule size leads to faster tableting speeds with improved quality and least rejections.

Salient Features:

• Homogeneous binder distribution.
• Short batch time and reduce cleaning time.
• Maximize CIP effectiveness.
• Air purge sealing system for main stirrer shaft and granulator shaft.
• All internal contact parts are polished to the mirror finish.
• PLC based operating panel for precise control of process & automation.
• A high-speed granulator is inserted horizontally through wall of bowl to assist blending of powder and to break the product to the granules of required size.
• The seal housing and drive shaft may be flushed with cleaning water, which is then
•   drained away from the machine through built in drain tubes.
• Granulator motor is provided with a removable stainless steel shroud which covers the motor and simplify cleaning.
• All moving part of the machine are totally enclosed to eliminate accident.
• The machine can not be started unless and until the mixer cover is properly closed.
• All contact parts are made out of SS304. SS316 provided on demand on extra cost.
• Flush wall type discharge valve eliminates pockets at the port of discharge valve.

Conical Mill + High Shear Mixer Granulator , Vacuum conveying + High Shear Mixer Granulator

Optional Facility Available On Demand At Extra Cost

 

Flameproof motors with flameproof operating panel.

 

Discharge provided on left or right side (as per granulation room layout) to suit client`s requirement.

 

• Granulation process requires less bind
• Granulation is achieved within a short time
• Greater densification and production of less friable granules
• The granulator produces reproducible less friable granules with a uniform particle size distribution
• High shear mixer minimizes the exposure of drug dust to workers due to reduced process dust generation
• The granulation endpoint is predictable while using a high shear mixer
• Saving 25% of adhesives and drying time
• It can be equipped with cone mill or swing granulator
• Connect with fluid bed dryer by vacuum conveying by vacuum conveying

 

 

Technical Details: :

Model available from 25 Liters to 1250 Liters capacity gross capacity.
The gross capacity & working capacity in liters and working capacity in Kgs. are mentioned on next page.

Mixer Granulator + Inline Mixer + High Shear Inline Mixer RMG – With Right Side Discharge Valve

 

Model	Gross Capacity in Litres	Working Capacity in Litres	Working Capacity in Kgs. At Bulk Density of Material 0.50 GMS/ CC
RMG – 60	60	45	25
RMG – 100	100	80	40
RMG – 150	150	120	60
RMG – 250	250	200	100
RMG – 400	400	320	150
RMG – 600	600	480	240
RMG – 750	750	600	300
RMG – 1250	1250	1000	500

Note: Dimensions & Technical Details are subject to change as per customers’ requirement without any further notice

Innovative designs that enhance solid dosage production. This helps in achieving top-notch pharmaceutical manufacturing operations ,Supplying pharmaceutical and industrial products such as High Shear Mixer, Fluid Bed Dryer, Fluid Bed Processor, Fluid Bed Granulator, Lifting column products, Cone Mill, Vacuum Conveying, Bin Blender, Coating machine, Clean Room System and many more.

 

high shear mixers, consists of frame, conical mixing bowl, three bladed impeller, chopper, motor to drive the blades and discharge system. According to your process requirements, wet cone mill is an optional item.

The materials feeding into the granulating pot through the vacuum. After the action of centrifugal force of impeller, the pressure liquid supply system injects the adhesive through the spray gun. At the same time, the chopper rotates at a high speed. The materials are bonded into granules in the bowl and discharged to the next process.

Rapid Mixer Granulators: Choppers, Impellers, Z Rotor

Shree Bhagwati shear mixer’s chopper has two modes of speeds: two speeds or variable speed. Main shaft and chopper shaft are designed with one-way flow air seal, flow rate, the pressure of air seal can be measured & controlled to prevent and detect powder or water from entering inside.

 

 

Shree Bhagwati high shear inline mixer auto controls stop position of the impeller, auto elevates the main shaft by pneumatic for the visible check without dismantling.

 

 

The all-important tool in the wet granulation is the bottom driven Z-Rotor. The unique geometry of the Z-Rotor ensures maximum efficiency while minimizing the power required. Cutting edge measuring and manufacturing processes ensure that the gap between the rotor/stator and the bottom of the working bowl is kept to a minimum while maximizing product yield.

 

Shree Bhagwati’s Unique high shear mixer technology is combined with easy handling. Our high shear homogenizer is of very fine quality with affordable prices. So if f you want to start a wet granulation equipment business, please contact us for more details, we will send you all quotations for machines, and drawings.

 

 

We offer free Customization & Consultancy services for Rapid Mixer Granulators

 

Shree Bhagwati high shear mixers can be customized according to your requirements, once you improve detailed user requirement statement(URS), we can supply the equipment line drawings and suggestion for your factory layout, and we will also provide you technical support without any additional cost.

Granulation helps promote the flowability, compressibility, bioavailability, and homogeneity of the API mix. There are different granulation methods and techniques, which influence the properties of the granules.

First, the major granulation line processes include:

1. Direct Compaction
2. Dry granulation
3. Wet granulation

Tests have shown that direct compaction leads to problems with the flow of powder and the grains sticks on the surface of machines during compression.

Binder liquids used include:

• Propan-2-ol/isopropanol (organic)
• Ethanol (organic)
• Water

Organic solvents (isopropanol and ethanol) are added to an API mix that can react with water (hydrolysis).

 

Specification Sheet – Granulation line equipment, wet granulation line, dry granulation line

MODEL	FULL CAPACITY	WORKING CAPACITY	WORKING BATCH (BD = 0.5G/C.C.)	MAIN DRIVE (60HZ)	MAIN DRIVE (60HZ)	CHOPPER DRIVE (60HZ)
	LITER	LITER	Kg/Batch	Kw	rpm	Kw
SB-SMG-20	20	7~14	4~7	2.5	172	0.75
SB-SMG-100	100	35~70	18~35	5.5	172	2.2
SB-SMG-150	150	53~105	26~53	11.2	172	3.7
SB-SMG-250	250	88~175	44~88	15	172	5.5
SB-SMG-300	300	105~210	53~105	22.5	160	5.5
SB-SMG-400	400	140~280	70~140	26.5	145	7.3
SB-SMG-600	600	210~420	105~210	37	120	11.2
SB-SMG-800	800	280~560	140~280	56	120	15
SB-SMG-1000	1000	350~700	175~350	75	180	22.5
SB-SMG-2000	2000	700~1400	350~700	132	145	37.5

Operation /Functions

1. Mixing: Powder and powder
2. Granulation: Powder and binder

 

Applications

• Pharmaceutical: Powder mixing, granulating with binder before tableting.
• Food: Fruit favored tablet, seasoning and healthy food granulation.
• Chemical material mixing and granulation.
• Electronic material mixing and granulation.

 

Laboratory Equipment

• Laboratory Models: SMG-3, SMG-5, SMG-10, SMG-20
  Laboratory Multi-bowl Model: SMG-3/2/1, SMG-10/5, SMG-20/10

 

Optional Devices Are Available

 

1. Solution spray system: by using pressure or pump to transfer.
   2. Human-Machine Interface (HMI) design
   3. The end point control of granulation: by ampere or Lorquet
   4. Explosion Proof Device: for organic solvent
   5. Jacket: for cooling or heating
   6. Discharge with Cone Mill, and can be connected to the Fluid Bed Dryer
   7. Material transfer: by vacuum suction or lifting system
   8. WIP system
   9. Main Impeller Lifting System for cleaning
   10. Preparation Tank

• All contact parts in SS 316L or FDA approved materials (gaskets, seals, filter bags etc.)
• 21-CFR part 11 compliance for data integrity and storage
• 3-modes with multi-level password access

 

Mixer Granulator is designed to meet special needs of tablet manufacturing technology. This is achieved by reduced processing time, more homogeneous mixing, uniformity of Granule size and above all maintaining improved hygiene compliant to cGMP norms.

International Standard Rapid Mixer Granulators

We are a leading high shear mixer manufacturer, and always at your disposal for any information required regarding high shear or rapid mixer granulators.

 

A High Shear Mixer Granulator (HSMG) is a type of pharmaceutical and industrial equipment used for the production of granules from powder or other solid materials. It’s commonly employed in industries such as pharmaceuticals, food processing, and chemical manufacturing. The primary purpose of a high shear mixer granulator is to combine powders and binders to form granules with the desired properties, such as size, density, and flowability.

Here’s how a high shear mixer granulator works:

1. Powder Mixing: Initially, the dry powders, which can include active pharmaceutical ingredients (APIs), excipients, binders, and fillers, are loaded into the mixing chamber of the granulator.

 

1. Wet Granulation: A liquid binder solution is added to the powders. This liquid can be water or a solvent containing binding agents. The mixing impeller, commonly referred to as a “chopper” or “impeller blade,” rotates at high speeds, causing the powders to mix and form wet aggregates.

 

1. Shearing and Granulation: As the impeller blade continues to rotate at high speeds, it creates shear forces and turbulence within the mixture. This shearing action breaks down larger wet aggregates into smaller particles, promoting uniform wetting and granule formation. The high shear forces also help in distributing the binder evenly, ensuring proper adhesion between particles.

 

1. Drying: After the desired granule size and uniformity are achieved, the wet granules are dried to remove the moisture added during the wet granulation process. Some high shear mixer granulators have built-in drying capabilities, while others might require transferring the wet granules to a separate drying unit.

 

1. Sizing and Sieving: Once the granules are dry, they might undergo sizing and sieving to achieve the desired particle size distribution.

High Shear Mixer Granulators offer several advantages:

• Efficient granule formation due to intense mixing and shearing forces.
• Enhanced uniformity of granules, leading to consistent product quality.
• Rapid and controlled wetting of powders, aiding in binder distribution.
• Flexibility to adjust parameters such as impeller speed, binder flow rate, and processing time.
• Potential reduction in processing time compared to traditional granulation methods.

However, there are some considerations:

• Equipment and maintenance costs can be relatively high.
• Process validation might be required for regulatory compliance in pharmaceutical manufacturing.
• The selection of appropriate binders and excipients is crucial for successful granulation.
• Operator training is essential to ensure safe and effective operation.

High Shear Granulation Machine – Evaluating the design must include all parts such as (not limited to these):

• Granulation Container
• Impeller Design
• Chopper Design
• Sealing Mechanism
• Drive Mechanism
• Granules Discharge
• Machine Frame and Structure
• Granules Milling
• Spraying Nozzle
• Electrical and Control Panel

 

Overall, high shear mixer granulators are valuable tools in industries where granule formation is a critical step in the manufacturing process. They enable efficient and controlled granulation, contributing to the production of high-quality products.