The Wall-Mounted High Containment Wet Granulation Line is a fully enclosed, contamination-free system designed for highly potent, toxic, and allergenic materials. Engineered for OEB4 and OEB5 containment, it provides maximum operator safety while delivering precise, reproducible granulation results for lab-scale and pilot-scale batches from 2 to 20 kg.

With a modular wall-mounted design, the system separates process equipment from technical utilities, ensuring improved GMP compliance, easy maintenance, and superior containment performance.

High Containment Highlights

  • Compliance: OEB4 / OEB5

  • Bag-In / Bag-Out air exhaust and filter replacement

  • Fully Closed Handling: No dust release; no open discharge

  • Integrated CIP/WIP: Cleaning nozzles inside pipes and product contact zones

  • Safe System Design: For HPAPI, oncology, hormone & steroid formulations

 

Why Wall-Mounted Granulation Line?

  • ✔ Separates cleanroom and technical area

  • ✔ Better operational safety

  • ✔ Easy access for maintenance

  • ✔ Reduced equipment footprint

  • ✔ Improved GMP compliance

  • ✔ Lower risk of cross-contamination

  • ✔ Ideal for HPAPI processing in regulated markets

Applications

Ideal for high-risk pharmaceutical formulations such as:

  • Oncology & anti-cancer drugs

  • Hormonal and steroid-based products

  • Highly potent APIs (HPAPI)

  • Allergenic & antibiotic powders

  • Clinical trial batches

  • R&D formulation development

  • Pilot-scale production (2–20 kg)

System Configuration (Wall-Mounted Design)

1. Sifter (Inline Sieving Unit)

  • Removes lumps, foreign materials, and ensures uniform particle size.

  • Dust-free feeding and discharge.

2. Rapid Mixer Granulator (RMG)

  • High-shear mixing and granulation.

  • Variable impeller/chopper speed.

  • Accurate binder dosing control.

  • Excellent granule consistency and reproducibility.

3. Fluid Bed Dryer (FBD)

  • Efficient drying using controlled airflow and temperature.

  • Safe exhaust handling with HEPA + BIBO module.

  • Optimized moisture control and uniform drying.

4. Co-Mill + Powder Transfer System

  • Post-drying milling for uniform granule size.

  • Closed-loop vacuum transfer ensures zero-exposure movement.

  • Perfect for HPAPI and dust-sensitive materials.

5. Blender (Bin/Octagonal/Double-Cone Options)

  • Final blending of dried granules and lubricants.

  • Ensures excellent content uniformity.

  • Optional contained discharge valves.

6. Tablet Coater (Optional)

  • For film, sugar, or enteric coating applications.

  • Available for lab and pilot-scale coating trials.

Batch Capacities Available

  • 2 kg Lab Model

  • 5 kg / 10 kg Lab-Pilot Model

  • 15 kg / 20 kg Pilot Model
    Custom capacities available on request.